Clomiphene Citrate Powder Legal Anabolic Steroids CAS 50-41-9
What is Clomiphene
Clomifene, also known as clomiphene, is a medication used to treat
infertility in women who do not ovulate. This includes those who
have polycystic ovary syndrome. Use results in a greater chance
of twins. It is taken by mouth once a day.
Common side effects include pelvic pain and hot flashes. Other
side effects can include changes in vision, vomiting, trouble
sleeping, ovarian cancer, and seizures. It is not recommended
in people with liver disease or who are pregnant. Clomifene is
in the selective estrogen receptor modulator (SERM) family of
medication. It works by causing the release of GnRH by the
hypothalamus, and subsequently gonadotropin from the anterior
Clomifene was approved for medical use in the United States in
1967. It is on the World Health Organization's List of Essential
Medicines, the most effective and safe medicines needed in a health
system. It is available as a generic medication.
Clomifene is one of several alternatives for ovulation induction in
those who are infertile due to anovulation or oligoovulation.
Evidence is lacking for the use of clomifene in those who are
infertile without a known reason. In such cases, studies have
observed a clinical pregnancy rate 5.6% per cycle with clomifene
treatment vs. 1.3%–4.2% per cycle without treatment.
Proper timing of the drug is important; it should be taken starting
on about the fifth day of the cycle, and there should be frequent
The following procedures may be used to monitor induced cycles
Follicular monitoring with vaginal ultrasound, starting 4–6 days
after last pill. Serial transvaginal ultrasound can reveal the size
and number of developing follicles. It can also provide presumptive
evidence of ovulation such as sudden collapse of the preovulatory
follicle, and an increase in fluid volume in the rectouterine
pouch. After ovulation, it may reveal signs of luteinization such
as loss of clearly defined follicular margins and appearance of
Serum estradiol levels, starting 4–6 days after last pill
Post-coital test 1–3 days before ovulation to check whether there
are at least 5 progressive sperm per HPF
Adequacy of LH surge by urine LH surge tests 3 to 4 days after last
Mid-luteal progesterone, with at least 10 ng/ml 7–9 days after
ovulation being regarded as adequate.
Repeat dosing: This 5-day treatment course can be repeated every 30
days. The dosage may be increased by 50-mg increments in subsequent
cycles until ovulation is achieved. It is not recommended by
the manufacturer to use clomifene for more than 6 cycles.
It is no longer recommended to perform an ultrasound examination to
exclude any significant residual ovarian enlargement before each
new treatment cycle.
How to use Clomiphene Citrate
Clomiphene must be taken by mouth exactly as directed by your
doctor in order to be most effective. It is important to follow
your dosing schedule carefully.
Your dosage is based on your medical condition and response to
therapy. Do not take it more often or for a longer time than
prescribed by your doctor. Long-term treatment with this medication
is not recommended and should not be more than 6 cycles.
You may be directed to record your body temperature, perform
ovulation tests, and properly time sexual intercourse for best
results. Ask your doctor if you have any questions.